Background: Neurotransmitters are the mediators of synaptic communication between neurons influencing various physiological and behavioral processes, and thus, understanding the mechanisms of their release and corelease is fundamental to understand brain function and plasticity in health and disease. Recent discoveries demystified traditional thinking that neurons release a single neurotransmitter, and characterized neurotransmitter corelease where single neurons release two or more different neurotransmitters or neuromodulators in an increasing number of neuronal population. This emerging area of research promises to uncover novel insights into the complexities of neural communication and its relevance to multiple diseases such as addiction to drugs of abuse.
Goal: The primary objective of this Research Topic is to showcase novel discoveries elucidating the role of neurotransmitter corelease and their mechanisms in neural circuits involved in reward and behavioral reinforcement and their potential roles in pathologies linked to these neurocircuits such as addiction. Addiction is a chronic condition characterized by compulsive drug-seeking behavior and a loss of control over substance use. Understanding how neurotransmitter corelease contributes to the circuit function and development of dysfunction in pathology can ultimately lead to new avenues for cutting-edge treatment and interventions strategies.
Our aim is to gather original research articles, reviews, and perspectives to highlight the central role of neurotransmitter corelease in reward and addiction-related processes. We encourage submissions that explore the impact of neurotransmitter corelease on neural circuit function, plasticity, dysfunction and adaptations associated with acute or chronic substance abuse, addiction vulnerability, development or relapse.
Scope and Information for Authors: This Research Topic invites contributions focusing on various aspects of neurotransmitter corelease and its implications in health and disease related to reward pathways and functions. Potential areas of interest include, but are not limited to:
•Role of neurotransmitter corelease in the neural circuits involved in goal-directed behaviors, motivation, reward, craving, and reinforcement mechanisms.
•Functional implications of neurotransmitter corelease in addiction-related behaviors and cognitive processes.
•Mechanisms underlying neurotransmitter corelease in addiction and its regulation.
•Plasticity and adaptations related to neurotransmitter corelease in addiction.
•Pharmacological interventions targeting corelease of neurotransmitters for the treatment of addiction.
Authors are encouraged to submit original research findings, comprehensive reviews, hypotheses, and theoretical perspectives. We aim to foster a multidisciplinary approach that integrates neurobiology, behavioral neuroscience, pharmacology, and clinical perspectives to advance our understanding of neurotransmitter corelease in the context of goal directed behaviors and addiction. By exploring this fascinating area of research, we aspire to pave the way for innovative therapeutic approaches to combat addiction and improve patient outcomes.
Keywords:neurotransmitter corelease, neurotransmission, co-transmission, reward, synaptic plasticity, addiction, substance abuse
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Background: Neurotransmitters are the mediators of synaptic communication between neurons influencing various physiological and behavioral processes, and thus, understanding the mechanisms of their release and corelease is fundamental to understand brain function and plasticity in health and disease. Recent discoveries demystified traditional thinking that neurons release a single neurotransmitter, and characterized neurotransmitter corelease where single neurons release two or more different neurotransmitters or neuromodulators in an increasing number of neuronal population. This emerging area of research promises to uncover novel insights into the complexities of neural communication and its relevance to multiple diseases such as addiction to drugs of abuse.
Goal: The primary objective of this Research Topic is to showcase novel discoveries elucidating the role of neurotransmitter corelease and their mechanisms in neural circuits involved in reward and behavioral reinforcement and their potential roles in pathologies linked to these neurocircuits such as addiction. Addiction is a chronic condition characterized by compulsive drug-seeking behavior and a loss of control over substance use. Understanding how neurotransmitter corelease contributes to the circuit function and development of dysfunction in pathology can ultimately lead to new avenues for cutting-edge treatment and interventions strategies.
Our aim is to gather original research articles, reviews, and perspectives to highlight the central role of neurotransmitter corelease in reward and addiction-related processes. We encourage submissions that explore the impact of neurotransmitter corelease on neural circuit function, plasticity, dysfunction and adaptations associated with acute or chronic substance abuse, addiction vulnerability, development or relapse.
Scope and Information for Authors: This Research Topic invites contributions focusing on various aspects of neurotransmitter corelease and its implications in health and disease related to reward pathways and functions. Potential areas of interest include, but are not limited to:
•Role of neurotransmitter corelease in the neural circuits involved in goal-directed behaviors, motivation, reward, craving, and reinforcement mechanisms.
•Functional implications of neurotransmitter corelease in addiction-related behaviors and cognitive processes.
•Mechanisms underlying neurotransmitter corelease in addiction and its regulation.
•Plasticity and adaptations related to neurotransmitter corelease in addiction.
•Pharmacological interventions targeting corelease of neurotransmitters for the treatment of addiction.
Authors are encouraged to submit original research findings, comprehensive reviews, hypotheses, and theoretical perspectives. We aim to foster a multidisciplinary approach that integrates neurobiology, behavioral neuroscience, pharmacology, and clinical perspectives to advance our understanding of neurotransmitter corelease in the context of goal directed behaviors and addiction. By exploring this fascinating area of research, we aspire to pave the way for innovative therapeutic approaches to combat addiction and improve patient outcomes.
Keywords:neurotransmitter corelease, neurotransmission, co-transmission, reward, synaptic plasticity, addiction, substance abuse
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
